Oliē Skin — Physician Guide
The 28-Day NeoPep
Activation Protocol
Activation Protocol
Dr. Neves's exact daily regimen. How to use the Oliē Peptide Serum to get the most out of the first 28 days of your 90-day protocol.
This guide exists because the order you apply your skincare matters. Peptides are active ingredients — they need to reach the dermis to work. How and when you apply them determines whether they get there. Follow this routine and you'll give the NeoPep Complex the best possible conditions to do what it was formulated to do.
Dr. Neves, Founder, Oliē
Daily Routine
Your AM and PM protocol.
Morning Routine
AM — takes 4 minutes
1
Gentle Cleanser
Wash face with a pH-balanced cleanser. No active exfoliants in the AM — save those for PM. Pat dry, don't rub.
2
Oliē Peptide Serum — 3 to 4 drops
Apply to clean, slightly damp skin. Press in with fingertips from center outward. Do not rub. Allow 60 seconds to absorb before next step.
3
Moisturizer
Lock in the serum with your moisturizer. Ceramide-based formulas work particularly well with peptides — they support the skin barrier that peptides are rebuilding.
4
SPF 30 or higher (non-negotiable)
Active peptides make your skin more responsive to UV damage. SPF in the morning is not optional during this protocol. Apply last.
Evening Routine
PM — takes 5 minutes
1
Double Cleanse (if wearing SPF or makeup)
Oil cleanser first, then water-based. You need a completely clean surface for the serum to penetrate effectively. Residue blocks absorption.
2
Oliē Peptide Serum — 3 to 4 drops
Apply to clean, damp skin. The PM application is your primary treatment window — skin repair peaks overnight. Press in, wait 90 seconds.
3
Moisturizer or Night Cream
Richer formulas are fine at night. The goal is to create an occlusive layer that keeps the peptides in contact with the dermis while you sleep.
4
Optional: Retinol (Week 3 onward only)
If you use retinol, do not apply it the same night as the serum for the first two weeks. From Week 3, alternating nights is acceptable. See the Synergy Guide for full details.
Week by Week
What to expect at each stage.
Week 1 — Days 1 to 7
Absorption phase
The NeoPep Complex begins saturating the dermis. Most women notice improved texture by Day 5. Some see glow as early as Day 3. This is the skin adjusting to active peptide delivery.
Week 2 — Days 8 to 14
First visible changes
Collagen stimulation begins building momentum. Fine lines around the eyes typically soften first. Skin feels structurally different to the touch, not just hydrated.
Week 3 — Days 15 to 21
Firmness builds
By Day 21 most women report that others have noticed a change. Skin feels tighter without feeling tight. This is the milestone Dr. Neves calls "reactivation confirmed."
Week 4 — Days 22 to 28
Foundation set
The first 28 days prime the skin for the deeper structural changes that come in Months 2 and 3. At this point, continuing the protocol compounds the results already built.
Application Tips
Details that make a difference.
- Apply to slightly damp skin, not wet skin. Damp allows absorption. Wet dilutes.
- Use 3 to 4 drops per application. More does not mean faster results. The formula is concentrated by design.
- Press, do not rub. Rubbing generates friction and moves the serum laterally instead of driving it inward.
- Let the serum sit for at least 60 seconds before applying moisturizer. Do not rush this step.
- Consistency matters more than frequency. Twice daily, every day, is more effective than four applications in one day and none the next.
- Store at room temperature, away from direct sunlight. Do not refrigerate.
- If redness appears in the first 3 days, reduce to once daily (PM only) for one week, then return to twice daily. This is the skin adjusting, not a reaction to avoid.